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Serotonin in the Pocket: Non-covalent interactions and neurotransmitter bindingLearning Objectives
- Students will design a binding site for the neurotransmitter serotonin.
- Students will be able to determine the effect of a change in molecular orientation on the affinity of the molecule for the binding site.
- Students will be able to determine the effect of a change in molecular charge on the affinity of the molecule for the binding site.
- Students will be able to better differentiate between hydrogen bond donors and acceptors.
- Students can use this knowledge to design binding sites for other metabolites.
Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle...Learning Objectives
- Students will define a Poisson distribution.
- Students will generate a data set on the probability of a T cell being infected with a virus(es).
- Students will predict the likelihood of one observing the mean value of viruses occurring.
- Students will evaluate the outcomes of a random process.
- Students will hypothesize whether a process is Poissonian and design a test for that hypothesis.
- Students will collect data and create a histogram from their data.
Out of Your Seat and on Your Feet! An adaptable course-based research project in plant ecology for advanced studentsLearning ObjectivesStudents will:
- Articulate testable hypotheses. (Lab 8, final presentation/paper, in-class exercises)
- Analyze data to determine the level of support for articulated hypotheses. (Labs 4-7, final presentation/paper)
- Identify multiple species of plants in the field quickly and accurately. (Labs 2-3, field trip)
- Measure environmental variables and sample vegetation in the field. (Labs 2-3, field trip)
- Analyze soil samples using a variety of low-tech lab techniques. (Open labs after field trip)
- Use multiple statistical techniques to analyze data for patterns. (Labs 4-8, final presentation/paper)
- Interpret statistical analyses to distinguish between strong and weak interactions in a biological system. (Labs 4-7, final presentation/paper)
- Develop and present a conference-style presentation in a public forum. (Lab 8, final presentation/paper)
- Write a publication-ready research paper communicating findings and displaying data. (Lab 8, final presentation/paper)
What do Bone and Silly Putty® have in Common?: A Lesson on Bone ViscoelasticityLearning Objectives
- Students will be able to explain how the anatomical structure of long bones relates to their function.
- Students will be able to define viscoelasticity, hysteresis, anisotropy, stiffness, strength, ductility, and toughness.
- Students will be able to identify the elastic and plastic regions of a stress-strain curve. They will be able to correlate each phase of the stress-strain curve with physical changes to bone.
- Students will be able to predict how a bone would respond to changes in the magnitude of an applied force, and to variations in the speed or angle at which a force is applied.
- Students will be able to determine the reason(s) why bone injuries occur more frequently during athletic events than during normal everyday use.
A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research ExperienceLearning Objectives
- Students will be able to evaluate the strengths and weaknesses of data.
- Students will be able to employ prior knowledge in formulating a biological research question or hypothesis.
- Students will be able to distinguish a research question from a testable hypothesis.
- Students will recognize that the following are essential elements in experimental design: identifying gaps in prior knowledge, picking an appropriate approach (ex. experimental tools and controls) for testing a hypothesis, and reproducibility and repeatability.
- Students will be able to identify appropriate experimental tools, approaches and controls to use in testing a hypothesis.
- Students will be able to accurately explain why an experimental approach they have selected is a good choice for testing a particular hypothesis.
- Students will be able to discuss whether experimental outcomes support or fail to support a particular hypothesis, and in the case of the latter, discuss possible reasons why.
A virtual laboratory on cell division using a publicly-available image databaseLearning Objectives
- Students will name and describe the salient features and cellular tasks for each stage of cell division.
- Students will predict the relative durations of the stages of cell division using prior knowledge and facts from assigned readings.
- Students will describe the relationship between duration of each stage of cell division and the frequency of cells present in each stage of cell division counted in a random sample of images of pluripotent stem cells.
- Students will identify the stages of cell division present in research-quality images of human pluripotent stem cells in various stages of cell division.
- Students will quantify, analyze and summarize data on the prevalence of cells at different stages of cell division in randomly sampled cell populations.
- Students will use data to reflect on and revise predictions.
Make It Stick: Teaching Gene Targeting with Ribbons and FastenersLearning Objectives
- Students will be able to design targeting constructs.
- Students will be able to predict changes to the gene locus after homologous recombination.
- Students will be able to design experiments to answer a biological question (e.g., "Design an experiment to test if the expression of gene X is necessary for limb development").
A Close-Up Look at PCRLearning ObjectivesAt the end of this lesson students will be able to...
- Describe the role of a primer in PCR
- Predict sequence and length of PCR product based on primer sequences
- Recognize that primers are incorporated into the final PCR products and explain why
- Identify covalent and hydrogen bonds formed and broken during PCR
- Predict the structure of PCR products after each cycle of the reaction
- Explain why amplification proceeds exponentially
Exploration of the Human Genome by Investigation of Personalized SNPsLearning ObjectivesStudents successfully completing this lesson will be able to:
- Effectively use the bioinformatics databases (SNPedia, the UCSC Genome Browser, and NCBI) to explore SNPs of interest within the human genome.
- Identify three health-related SNPs of personal interest and use the UCSC Genome Browser to define their precise chromosomal locations and determine whether they lie within a gene or are intergenic.
- Establish a list of all genome-wide association studies correlated with a particular health-related SNP.
- Predict which model organism would be most appropriate for conducting further research on a human disease.
You and Your Oral Microflora: Introducing non-biology majors to their “forgotten organ”Learning ObjectivesStudents will be able to:
- Explain both beneficial and detrimental roles of microbes in human health.
- Compare and contrast DNA replication as it occurs inside a cell versus in a test tube
- Identify an unknown sequence of DNA by performing a BLAST search
- Navigate sources of scientific information to assess the accuracy of their experimental techniques
The Case of the Missing Strawberries: RFLP analysisLearning ObjectivesStudents will be able to:
- Describe the relationship of cells, chromosomes, and DNA.
- Isolate DNA from strawberries.
- Digest DNA with restriction enzymes.
- Perform gel electrophoresis.
- Design an experiment to compare DNAs by RFLP analysis.
- Predict results of RFLP analysis.
- Interpret results of RFLP analysis.
- Use appropriate safety procedures in the lab.
Taking the Hassle out of HasselbalchLearning ObjectivesStudents will be able to:
- Characterize an aqueous environment as acidic or basic.
- Explain that pKa is a measure of how easy it is to remove a proton from a molecule.
- Predict ionization state of a molecule at a particular pH based on its pKa (qualitative use of the Henderson-Hasselbalch equation).
- Calculate the ratio of protonated/unprotonated forms of ionizable groups depending on chemical characteristics and /or environment pH (quantitative use of the Henderson-Hasselbalch equation).
- Apply this knowledge in a medical context.
Lights, Camera, Acting Transport! Using role-play to teach membrane transportLearning ObjectivesAt the end of this activity, students should be able to:
- Compare and contrast the mechanisms of simple diffusion, facilitated diffusion, and active transport (both primary and secondary).
- Identify, and provide a rationale for, the mechanism(s) by which various substances cross the plasma membrane.
- Describe the steps involved in the transport of ions by the Na+/K+ pump, and explain the importance of electrogenic pumps to the generation and maintenance of membrane potentials.
- Explain the function of electrochemical gradients as potential energy sources specifically used in secondary active transport.
- Relate each molecule or ion transported by the Na+/glucose cotransporter (SGLT1) to its own concentration or electrochemical gradient, and describe which molecules travel with and against these gradients.
Meiosis: A Play in Three Acts, Starring DNA SequenceLearning Objectives
- Students will be able to identify sister chromatids and homologous chromosomes at different stages of meiosis.
- Students will be able to identify haploid and diploid cells, whether or not the chromosomes are replicated.
- Students will be able to explain why homologous chromosomes must pair during meiosis.
- Students will be able to relate DNA sequence similarity to chromosomal structures.
- Students will be able to identify crossing over as the key to proper pairing of homologous chromosomes during meiosis.
- Students will be able to predict the outcomes of meiosis for a particular individual or cell.
Modeling the Research Process: Authentic human physiology research in a large non-majors courseLearning ObjectivesStudents will be able to:
- Read current scientific literature
- Formulate testable hypotheses
- Design an experimental procedure to test their hypothesis
- Make scientific observations
- Analyze and interpret data
- Communicate results visually and orally