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Casting a Wide Net via Case Studies: Educating across the undergraduate to medical school continuum in the biological...Learning ObjectivesAt the end of this lesson, the student should be able to:
- Consider the potential advantages and disadvantages of widespread use of whole genome sequencing and direct-to-consumer genetic testing.
- Explore the critical need to maintain privacy of individual genetic test results to protect patient interests.
- Dissect the nuances of reporting whole genome sequencing results.
- Recognize the economic ramifications of precision medicine strategies.
- Formulate a deeper understanding of the ethical dimensions of emerging genetic testing technologies.
Out of Your Seat and on Your Feet! An adaptable course-based research project in plant ecology for advanced studentsLearning ObjectivesStudents will:
- Articulate testable hypotheses. (Lab 8, final presentation/paper, in-class exercises)
- Analyze data to determine the level of support for articulated hypotheses. (Labs 4-7, final presentation/paper)
- Identify multiple species of plants in the field quickly and accurately. (Labs 2-3, field trip)
- Measure environmental variables and sample vegetation in the field. (Labs 2-3, field trip)
- Analyze soil samples using a variety of low-tech lab techniques. (Open labs after field trip)
- Use multiple statistical techniques to analyze data for patterns. (Labs 4-8, final presentation/paper)
- Interpret statistical analyses to distinguish between strong and weak interactions in a biological system. (Labs 4-7, final presentation/paper)
- Develop and present a conference-style presentation in a public forum. (Lab 8, final presentation/paper)
- Write a publication-ready research paper communicating findings and displaying data. (Lab 8, final presentation/paper)
Cutthroat trout in Colorado: A case study connecting evolution and conservationLearning ObjectivesStudents will be able to:
- interpret figures such as maps, phylogenies, STRUCTURE plots, and networks for species delimitation
- identify sources of uncertainty and disagreement in real data sets
- propose research to address or remedy uncertainty
- construct an evidence-based argument for the management of a rare taxon
Teaching epidemiology and principles of infectious disease using popular media and the case of Typhoid MaryLearning ObjectivesStudents will be able to:
- Describe the reservoirs of infection in humans.
- Distinguish portals of entry and exit.
- Describe how each of the following contributes to bacterial virulence: adhesins, extracellular enzymes, toxins, and antiphagocytic factors.
- Define and distinguish etiology and epidemiology.
- Describe the five typical stages of infectious disease and depict the stages in graphical form.
- Contrast contact, vehicle and vector transmission, biological and mechanical vectors and identify the mode of transmission in a given scenario.
- Differentiate endemic, sporadic, epidemic, and pandemic disease.
- Distinguish descriptive, analytical, and experimental epidemiology.
- Compare and contrast social, economic, and cultural factors impacting health care in the early 1900s and today.
Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeographyLearning ObjectivesStudents will be able to:
- Estimate phylogenetic trees using diverse data types and phylogenetic models.
- Correctly make inferences about evolutionary history and relatedness from the tree diagrams obtained.
- Use selected computer programs for phylogenetic analysis.
- Use bootstrapping to assess the statistical support for a phylogeny.
- Use phylogenetic data to construct, compare, and evaluate the role of geologic processes in shaping the historical and current geographic distributions of a group of organisms.
Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence...Learning ObjectivesAt the end of this lesson, students will be able to:
- Define similarity in a non-biological and biological sense when provided with two strings of letters.
- Quantify the similarity between two gene/protein sequences.
- Explain how a substitution matrix is used to quantify similarity.
- Calculate amino acid similarity scores using a scoring matrix.
- Demonstrate how to access genomic data (e.g., from NCBI nucleotide and protein databases).
- Demonstrate how to use bioinformatics tools to analyze genomic data (e.g., BLASTP), explain a simplified BLAST search algorithm including how similarity is used to perform a BLAST search, and how to evaluate the results of a BLAST search.
- Create a nearest-neighbor distance matrix.
- Create a multiple sequence alignment using a nearest-neighbor distance matrix and a phylogram based on similarity of amino acid sequences.
- Use appropriate bioinformatics sequence alignment tools to investigate a biological question.
Priority Setting in Public Health: A lesson in ethics and hard choicesLearning ObjectivesAt the end of this unit, students will be able to:
- Define the central distinction between public health and medicine
- Apply objectives of public health and individual medical care in a particular situation to identify potential areas of conflict in priority setting
- Apply moral theories of utilitarianism and deontology to a particular situation to identify the course of action proponents of each theory would see as morally justified
- Identify the range of morally justifiable actions that might be available to a health professional in a particular setting
- Choose from among a range of possible actions in a particular health situation and articulate the ethical principles that would justify that choice.