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  • A schematic of the relationship between the different types of pasta or beans and the respective gut and environmental bacteria

    The impact of diet and antibiotics on the gut microbiome

    Learning Objectives
    After completing the exercise, students will be able to:
    • Identify several of the nine phyla that contribute to the gut microbiome and name the two predominant ones;
    • Describe how diet impacts the gut microbiome and compare the composition of the gut microbiome between different diets;
    • Describe how antibiotic treatment impacts the gut microbiome and understand how this leads to infection, for example by Clostridium difficile;
    • Trace the response to a change in diet, starting with i) changes in the composition of the microbiome, followed by ii) changes in the bacterial metabolic pathways and the respective excreted metabolic products, resulting in iii) a molecular response in the host intestinal cells, and eventually iv) resulting in human disease;
    • Improve their ability to read scientific literature;
    • Express themselves orally and in writing;
    • Develop team working skill
  • SNP model by David Eccles (gringer) [GFDL (http://www.gnu.org/copyleft/fdl.html) or CC BY 4.0 (http://creativecommons.org/licenses/by/4.0)], via Wikimedia Commons

    Exploration of the Human Genome by Investigation of Personalized SNPs

    Learning Objectives
    Students successfully completing this lesson will be able to:
    • Effectively use the bioinformatics databases (SNPedia, the UCSC Genome Browser, and NCBI) to explore SNPs of interest within the human genome.
    • Identify three health-related SNPs of personal interest and use the UCSC Genome Browser to define their precise chromosomal locations and determine whether they lie within a gene or are intergenic.
    • Establish a list of all genome-wide association studies correlated with a particular health-related SNP.
    • Predict which model organism would be most appropriate for conducting further research on a human disease.