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- (-) Remove Answer clicker-type question(s) filter Answer clicker-type question(s)
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Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in HumansLearning Objectives
- Use biological databases to generate and compare lists of predicted miR targets, and obtain the mRNA sequence of their selected candidate gene
- Use bioinformatics tools to design and optimize primer sets for qPCR
A clicker-based case study that untangles student thinking about the processes in the central dogmaLearning ObjectivesStudents will be able to:
- explain the differences between silent (no change in the resulting amino acid sequence), missense (a change in the amino acid sequence), and nonsense (a change resulting in a premature stop codon) mutations.
- differentiate between how information is encoded during DNA replication, transcription, and translation.
- evaluate how different types of mutations (silent, missense, and nonsense) and the location of those mutations (intron, exon, and promoter) differentially affect the processes in the central dogma.
- predict the molecular (DNA size, mRNA length, mRNA abundance, and protein length) and/or phenotypic consequences of mutations.
Translating Co-Translational TranslocationLearning ObjectivesStudents will be able to:
- list the steps of co-translational translocation in the correct order.
- describe the key functions of molecules involved in co-translational translocation.
- predict the outcome of co-translational translocation if one of the components is missing.
- identify the characteristics of N-terminal ER signal sequences and internal ER signal sequences.
- predict or interpret the results of a protease protection assay used to assess co-translational translocation or transmembrane protein topology.
- predict the topology of a co-translationally translocated protein when given a description of the ER signal sequence or predict the type of ER signal sequence encoded by the mRNA-based protein topology.