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Priority Setting in Public Health: A lesson in ethics and hard choicesLearning ObjectivesAt the end of this unit, students will be able to:
- Define the central distinction between public health and medicine
- Apply objectives of public health and individual medical care in a particular situation to identify potential areas of conflict in priority setting
- Apply moral theories of utilitarianism and deontology to a particular situation to identify the course of action proponents of each theory would see as morally justified
- Identify the range of morally justifiable actions that might be available to a health professional in a particular setting
- Choose from among a range of possible actions in a particular health situation and articulate the ethical principles that would justify that choice.
Exploration of the Human Genome by Investigation of Personalized SNPsLearning ObjectivesStudents successfully completing this lesson will be able to:
- Effectively use the bioinformatics databases (SNPedia, the UCSC Genome Browser, and NCBI) to explore SNPs of interest within the human genome.
- Identify three health-related SNPs of personal interest and use the UCSC Genome Browser to define their precise chromosomal locations and determine whether they lie within a gene or are intergenic.
- Establish a list of all genome-wide association studies correlated with a particular health-related SNP.
- Predict which model organism would be most appropriate for conducting further research on a human disease.
The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching LaboratoriesLearning Objectives
- Test hypotheses related to the role of ACTN3 in skeletal muscle function.
- Explain how polymorphic variants of the ACTN3 gene affect protein structure and function.
- List and explain the differences between fast twitch and slow twitch muscle fibers.
- List and explain possible roles of the ACTN3 protein in skeletal muscle function.
- Find and analyze relevant scientific publications about the relationship between ACTN3 genotype and muscle function.
- Formulate hypotheses related to the relationship between ACTN3 genotype and skeletal muscle function.
- Design experiments to test hypotheses about the role of ACTN3 in skeletal muscle function.
- Statistically analyze experimental results using relevant software.
- Present experimental results in writing.
Air Quality Data Mining: Mining the US EPA AirData website for student-led evaluation of air quality issuesLearning ObjectivesStudents will be able to:
- Describe various parameters of air quality that can negatively impact human health, list priority air pollutants, and interpret the EPA Air Quality Index as it relates to human health.
- Identify an air quality problem that varies on spatial and/or temporal scales that can be addressed using publicly available U.S. EPA air data.
- Collect appropriate U.S. EPA Airdata information needed to answer that/those questions, using the U.S. EPA Airdata website data mining tools.
- Analyze the data as needed to address or answer their question(s).
- Interpret data and draw conclusions regarding air quality levels and/or impacts on human and public health.
- Communicate results in the form of a scientific paper.
Teaching epidemiology and principles of infectious disease using popular media and the case of Typhoid MaryLearning ObjectivesStudents will be able to:
- Describe the reservoirs of infection in humans.
- Distinguish portals of entry and exit.
- Describe how each of the following contributes to bacterial virulence: adhesins, extracellular enzymes, toxins, and antiphagocytic factors.
- Define and distinguish etiology and epidemiology.
- Describe the five typical stages of infectious disease and depict the stages in graphical form.
- Contrast contact, vehicle and vector transmission, biological and mechanical vectors and identify the mode of transmission in a given scenario.
- Differentiate endemic, sporadic, epidemic, and pandemic disease.
- Distinguish descriptive, analytical, and experimental epidemiology.
- Compare and contrast social, economic, and cultural factors impacting health care in the early 1900s and today.
Bad Science: Exploring the unethical research behind a putative memory supplementLearning ObjectivesStudents will be able to:
- create criteria for evaluating information that is touted as scientific.
- apply those criteria to evaluate the claim that Prevagen® enhances memory.
- identify the misleading tactics used on the Prevagen® website and in their self-published reporting.
- decide whether to recommend taking Prevagen® and explain their decisions.
Cutthroat trout in Colorado: A case study connecting evolution and conservationLearning ObjectivesStudents will be able to:
- interpret figures such as maps, phylogenies, STRUCTURE plots, and networks for species delimitation
- identify sources of uncertainty and disagreement in real data sets
- propose research to address or remedy uncertainty
- construct an evidence-based argument for the management of a rare taxon
Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide,...Learning ObjectivesAt the end of this lesson, students will be able to:
- Describe the roles of light energy and carbon dioxide in photosynthetic organisms.
- Identify the effect of nutrients on the growth of photosynthetic organisms.
- Describe global cycles in atmospheric carbon dioxide levels and how they relate to photosynthetic organisms.
Using Structured Decision Making to Explore Complex Environmental IssuesLearning ObjectivesStudents will be able to:
- Describe the process, challenges, and benefits of structured decision making for natural resource management decisions.
- Explain and reflect on the role of science and scientists in structured decision making and how those roles interact and compare to the roles of other stakeholders.
- Assess scientific evidence for a given management or policy action to resolve an environmental issue.
A flexible, multi-week approach to plant biology - How will plants respond to higher levels of CO2?Learning ObjectivesStudents will be able to:
- Apply findings from each week's lesson to make predictions and informed hypotheses about the next week's lesson.
- Keep a detailed laboratory notebook.
- Write and peer-edit the sections of a scientific paper, and collaboratively write an entire lab report in the form of a scientific research paper.
- Search for, find, and read scientific research papers.
- Work together as a team to conduct experiments.
- Connect findings and ideas from each week's lesson to get a broader understanding of how plants will respond to higher levels of CO2 (e.g., stomatal density, photosynthetic/respiratory rates, foliar protein concentrations, growth, and resource allocation).
Evaluating the Quick Fix: Weight Loss Drugs and Cellular RespirationLearning Objectives
- Students will be able to explain how the energy from sugars is transformed into ATP via cellular respiration.
- Students will be able to predict an outcome if there is a perturbation in the cellular respiration pathway.
- Students will be able to state and evaluate a hypothesis.
- Students will be able to interpret data from a graph, and use that data to make inferences about the action of a drug.
Antibiotic Resistance Genes Detection in Environmental SamplesLearning ObjectivesAfter completing this laboratory series, students will be able to:
- apply the scientific method in formulating a hypothesis, designing a controlled experiment using appropriate molecular biology techniques, and analyzing experimental results;
- conduct a molecular biology experiment and explain the principles behind methodologies, such as accurate use of micropipettes, PCR (polymerase chain reaction), and gel electrophoresis;
- determine the presence of antibiotic-resistance genes in environmental samples by analyzing PCR products using gel electrophoresis;
- explain mechanisms of microbial antibiotic resistance;
- contribute data to the Antibiotic Resistance Genes Network;
- define and apply key concepts of antibiotic resistance and gene identification via PCR fragment size.
Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental designLearning ObjectivesModule 1
- Generate a testable hypothesis that requires a creative design of reagents based on critical reading of and review of prior research.
- Demonstrate proficiency in using molecular cloning software to analyze, manipulate and verify DNA sequences.
- Predict the downstream effect on the mRNA and protein after successfully inserting a DNA repair template into the genome of a cell/organism.
- Compare and contrast the processes of DNA duplication and PCR.
- Demonstrate the ability to design primers to amplify a nucleotide sequence.
- Analyze and evaluate the results of DNA agarose gel electrophoresis.
- Identify the key features in genomic DNA, specifically those required for CRISPR-Cas9 mediated gene edits.
- Explain how compatible ends of DNA are used to produce recombinant DNA in a ligation reaction.
- Explain the chemical principles behind plasmid DNA purification from bacterial cultures.
- Devise a strategy to screen clones based on antibiotic selection and the mechanism of digestion by DNA endonucleases.
- Predict and evaluate the results of a diagnostic digest.
- Explain the chemical principles behind DNA purification using phenol-chloroform extraction and ethanol precipitation.
- Explain the key differences between DNA duplication and transcription.
- Demonstrate the ability to perform lab work with sterile technique.
- Compare and contrast the results of a non-denaturing vs. denaturing agarose gel.
- Evaluate the results of a denaturing agarose gel.
- Design and implement an experiment that tests the CRISPR-Cas9 principle.
- Predict the outcome of a successful in vitro Cas9 digest.
- Summarize important background information on gene of interest from analysis of primary literature.
- Produce figures and figure legends that clearly indicate results.
- Organize and construct a poster that clearly and professionally displays the important aspects of the lesson.
- Demonstrate understanding of the lesson by presenting a poster to an audience in lay terms, mid-level terms, or at an expert level.
- Demonstrate understanding of procedures by writing a formal materials and methods paper.
Your Tax Dollars at Work: A mock grant writing experience centered on scientific process skillsLearning ObjectivesStudents will be able to:
- Propose a testable, novel question contributing to a biological field of study.
- Formulate a study rationale.
- Describe relevant background information on a topic using the primary literature.
- Choose appropriate scientific, mathematical, and statistical methods to analyze a research question.
- Determine the financial costs of a research project.
- Present a proposal for peer review and compose a constructive peer review.
- Collaborate as a member of a scientific team.
- Articulate the review criteria and process used in NSF-style proposal review.
Sex and gender: What does it mean to be female or male?Learning Objectives
- Students will be able to distinguish between sex and gender, and apply each term appropriately.
- Students will be able to compare and contrast levels of sexual determination.
- Students will be able to critique societal misrepresentations surrounding sex, gender, and gender identity.