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Cell Biology

  • Images of students participating in the SIDE activity

    Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel

    Learning Objectives
    • Students will be able to analyze data from multiple experimental methodologies to determine the identity of their "mystery" TRP channel.
    • Students will be able to interpret the results of individual experiments and from multiple experiments simultaneously to identify their "mystery" TRP channel.
    • Students will be able to evaluate the advantages and limitations of experimental methodologies presented in this lesson.
  • Structure of protein ADA2

    Understanding Protein Domains: A Modular Approach

    Learning Objectives
    • Students will be able to compare protein sequences and identify conserved regions and putative domains.
    • Students will be able to obtain, examine, and compare structural models of protein domains.
    • Students will be able to interpret data on protein interactions (in vitro pull-down and in vitro and in vivo functional assays)
    • Students will be able to propose experiments to test protein interactions.
  • Arabidopsis Seedling

    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

    Learning Objectives
    Students will be able to:
    • identify when germination occurs.
    • score germination in the presence and absence of GA to construct graphs of collated class data of wild-type and mutant specimens.
    • identify the genotype of an unknown sample based on the analysis of their graphical data.
    • organize data and perform quantitative data analysis.
    • explain the importance of GA for plant germination.
    • connect the inheritance of a mutation with the observed phenotype.
  • Example image of dividing cells obtained from the Allen Institute for Cell Science 3D Cell Viewer.

    A virtual laboratory on cell division using a publicly-available image database

    Learning Objectives
    • Students will name and describe the salient features and cellular tasks for each stage of cell division.
    • Students will predict the relative durations of the stages of cell division using prior knowledge and facts from assigned readings.
    • Students will describe the relationship between duration of each stage of cell division and the frequency of cells present in each stage of cell division counted in a random sample of images of pluripotent stem cells.
    • Students will identify the stages of cell division present in research-quality images of human pluripotent stem cells in various stages of cell division.
    • Students will quantify, analyze and summarize data on the prevalence of cells at different stages of cell division in randomly sampled cell populations.
    • Students will use data to reflect on and revise predictions.
  • Two cells stained

    Bad Cell Reception? Using a cell part activity to help students appreciate cell biology, with an improved data plan and...

    Learning Objectives
    • Identify cell parts and explain their function
    • Explain how defects in a cell part can result in human disease
    • Generate thought-provoking questions that expand upon existing knowledge
    • Create a hypothesis and plan an experiment to answer a cell part question
    • Find and reference relevant cell biology journal articles
  • Sample Student Growth Curve. This image shows a yeast growth curve generated by a student in our lab, superimposed on an image of Saccharomyces cerevisiae cells.

    Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory

    Learning Objectives
    • Learn about basic S. cerevisiae biology
    • Use sterile technique
    • Perform a yeast viability assay
    • Use a spectrophotometer to measure growth of S. cerevisiae
    • Perform a literature search
    • Calculate concentrations of chemicals appropriate for S. cerevisiae
    • Generate S. cerevisiae growth curves
    • Troubleshoot experimental difficulties
    • Perform statistical analysis
    • Present findings to an audience
  • Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration Image File: QuickFixPrimImage.tiff Sources for images: Balance: Public Domain CCO http://www.pd4pic.com/scales-justice-scale-libra-balance-weighbridge.html Mitochondria: https://thumb7.shutterstock.com/thumb_large/1503584/235472731/stock-vector-mitochondrion-235472731.jpg Pills: https://pixabay.com/static/uploads/photo/2014/07/05/15/16/pills-384846_960_720.jpg

    Evaluating the Quick Fix: Weight Loss Drugs and Cellular Respiration

    Learning Objectives
    • Students will be able to explain how the energy from sugars is transformed into ATP via cellular respiration.
    • Students will be able to predict an outcome if there is a perturbation in the cellular respiration pathway.
    • Students will be able to state and evaluate a hypothesis.
    • Students will be able to interpret data from a graph, and use that data to make inferences about the action of a drug.