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Organogenesis

Developmental Biology Learning Framework

Society Learning Goals Articles Sample Learning Objectives
Organogenesis
How do extracellular factors control organ and tissue growth?
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  • Predict the outcome of a mutation that inhibits Frizzled (Wnt receptor) v. nCAMs
How does asymmetry arise and contribute to complexity? (localized determinants, cilia directional movement, etc.)
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  • Describe the mechanism whereby physical or chemical signals are used as an asymmetrical developmental trigger in plant or animal cells.
What roles do cell determination and cell specification play in organogenesis?
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  • Predict the lineage outcome (heart or tail) of transplanting mesodermal cell populations from anterior heart fields to posterior presomitic tail bud.
How do morphogen gradients regulate tissue organization?
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  • Describe the mechanism whereby physical or chemical signals are used as a developmental trigger in plant or animal cells and tissues.
How do differential cell adhesion, attraction and repulsion, and ECM regulate tissue organization?
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  • Interpret the effects of lateral inhibition in establishing neural fates. Explain why neural crest cells migrate across a specific part of the somite?
How do developmental processes affect tissue homeostasis and restoration?
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  • Compare and contrast muscle regeneration and myogenesis.

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