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Biochemistry and Molecular Biology Learning Framework

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Information storage and flow are dynamic and interactive
What is a genome?	An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design	show Define what a genome consists of and how the information in the various genes and other sequence classes within each genome is used to store and express genetic information. Discuss how the genome is organized and packaged in prokaryotes and eukaryotes. Discuss tools used to study expression, conservation and structure of an organism at the genome level. Explain the role of repetitive and non-repetitive DNA and how its relative abundance varies from prokaryotes to eukaryotes.
How does the nucleotide sequence of the gene lead to biological function?	An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design	show Explain the role of repetitive and non-repetitive DNA and how its relative abundance varies from prokaryotes to eukaryotes. Explain the process of gene regulation connecting how extracellular signals can result in a change of gene expression. Discuss how genes are organized and contrast the different approaches used in prokaryotic and eukaryotic organisms. Explain how mRNA processing occurs and how splicing affects the diversity of gene products in eukaryotic organisms.
How do genomes transmit information from one generation to the next?	A virtual laboratory on cell division using a publicly-available image database CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students	show Explain the differences of mitosis and meiosis and relate them to the process of cellular division. Illustrate how DNA is replicated and genes are transmitted from one generation to the next in multiple types of organisms including bacteria, eukaryotes, viruses and retroviruses. Apply the concepts of segregation and independent assortment to traits inherited from parent to offspring and discuss how they increase genetic variation.
How are genomes maintained?	Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design	show State how the cell ensures high fidelity DNA replication and identify instances where the cell employs mechanism for damage repair. Explain what a mutation is at the molecular level, how it arises and how it could potentially affect the organism from gene expression to fitness. Relate how the cell cycle and genome maintenance are coordinated and how disruptions in this coordination could affect the organism. List events that result in genomic instability and explain how the cell responds to restore order and stability. Construct relationships between chromosome and cellular structures (e.g. telomere, centromeres and centrosomes) and explain how these structures are responsible for and/or involved in genomic stability.