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Genetic variation

Genetics Learning Framework

Society Learning Goals Articles Sample Learning Objectives
Genetic variation
How do different types of mutations affect genes and the corresponding mRNAs and proteins?
  • Describe how duplications, deletions, inversions, and translocations can affect gene function, gene expression, and genetic recombination. Describe the same for transposable elements.
  • Describe how mutations arise and how environmental factors can increase mutation rate.
  • Cite examples of mutations that can be beneficial to organisms.
  • Interpret results from experiments to distinguish between different types of DNA rearrangements.
  • Distinguish between loss of function and gain of function mutations and their potential phenotypic consequences.
  • Predict the most likely effects on protein structure and function of null, reduction-of-function, overexpression, dominant-negative and gain-of-function mutations.
  • Compare the role of both loss and gain of function mutations in the origin of tumors


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