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What effects can the environment have on gene expression?

Topic

Biological information

Framing Question

What effects can the environment have on gene expression?

Learning Objectives

  • Discuss the role that nutrition plays in regulating transcription factors.
  • List the changes that toxicants may induce in the protein structure, nucleic acid sequence, and/or fatty acid metabolites.
  • Describe mechanisms of epigenetic transfer of information.
  • Describe how toxicants can induce changes in epigenetic information that can be transferred to subsequent generations.
  • Describe how gene/ environment/time interactions affect developmental disorders and disorders of aging.
  • Describe features of model systems used to examine gene/ environment interactions.
  • Describe toxicant/toxin effects on gene expression.
  • Describe genetic polymorphisms that affect toxicokinetics and risk.

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