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What differences occur in how individuals or populations are affected by exposure to different doses of a toxicant?

Topic

Biological information

Framing Question

What differences occur in how individuals or populations are affected by exposure to different doses of a toxicant?

Learning Objectives

  • Explain how differences in individuals result in differences in susceptibility of a population to toxicants.
  • Explain why inbred animals are used in many toxicological tests.
  • Contrast idiosyncratic reactions with other kinds of variation
  • in a population’s response to a toxicant.
  • Contrast Margin of Safety with Therapeutic Index with regards to prediction of drug safety in a
  • population.
  • Explain the concept of dose spacing in terms of toxicity.
  • Describe the concept of hormesis as it applies to toxicology.

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