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How have xenobiotic defense mechanism evolved?

Topic

Evolution

Framing Question

How have xenobiotic defense mechanism evolved?

Learning Objectives

  • Discuss the role of xenobiotic defense mechanisms in protection of organisms from toxicants and toxins.
  • Explain how evolution informs the development of the cytochrome P450 superfamily of genes.
  • Explain how evolution drives resistance to toxicants, toxins, metals, and radiation.
  • Describe how knowledge of genetic information can predict function of similar genes within the same organism or in other organisms.

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