Skip to main content

You are here

How do concepts of administration, distribution, metabolism, and elimination(ADME) help characterize the mechanism of action of toxicants?

Topic

Pathways and transformations of energy and matter

Framing Question

Describe how alterations in homeostasis can affect an individual’s dose-response.How do concepts of administration, distribution, metabolism, and elimination(ADME) help characterize the mechanism of action of toxicants?

Learning Objectives

  • Describe the fundamental basis of xenobiotic defense through ADME.
  • Explain why LD50is commonly used as a measure of toxicity of a compound.
  • Describe the concept of ADME as it relates to toxicant exposure.
  • Contrast the major sites of entry for toxicants and how site of entry affects dose and risk.
  • Describe features of chemicals and barriers that affect absorption of compounds.
  • Contrast the mechanisms of elimination, including excretion, storage, and biotransformation.

Courses

Courses