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How can ADME be quantified using toxicodynamics and toxicokinetics (TDTK)?

Topic

Pathways and transformations of energy and matter

Framing Question

How can ADME be quantified using toxicodynamics and toxicokinetics (TDTK)?

Learning Objectives

  • Define toxicokinetics, pharmacokinetics, toxicodynamics, and pharmacodynamics.
  • Explain how toxicokinetic studies are used to determine changes in concentration of a chemical and its metabolites over time in blood and other tissues.
  • Explain several methods of toxicokinetic analysis.
  • Describe how one-, two-, or multi-compartment models are used to approximate toxicokinetics.
  • Describe how saturation affects the elimination of a compound.
  • Contrast zero-order versus first- order kinetics of elimination.
  • Describe how barriers (e.g., blood-brain barrier or placenta) alter toxicokinetics.
  • Apply mathematical and computation methods to toxicokinetics.

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