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How are organs affected by exposure to toxicants?

Topic

Systems toxicology

Framing Question

How are organs affected by exposure to toxicants?

Learning Objectives

  • Identify and describe organ toxicity emanating from therapeutic and nontherapeutic (intentional and unintentional) drug/chemical exposures.
  • Recognize system-specific and organ-specific toxic effects on humans and other experimental models.
  • Predict/explain possible toxicological consequences after exposure to one or more drugs/chemicals within safe limits.
  • Describe the importance of the bioactivation process for prodrugs.
  • Decipher the mechanisms for drug and chemical-induced toxicity in in vivo and in vitro models and appropriately design and interpret drug screenings.
  • Discuss the important role the liver plays in xenobiotic metabolism.
  • List the characteristics that enable the kidney to efficiently excrete xenobiotics.
  • Recognize system-specific and organ-specific toxic effects on humans and other experimental models.
  • Describe the characteristics of the nervous system that make it vulnerable to many toxicants.

Courses

Courses