Topic
Systems toxicology
Framing Question
How are organs affected by exposure to toxicants?
Learning Objectives
- Identify and describe organ toxicity emanating from therapeutic and nontherapeutic (intentional and unintentional) drug/chemical exposures.
- Recognize system-specific and organ-specific toxic effects on humans and other experimental models.
- Predict/explain possible toxicological consequences after exposure to one or more drugs/chemicals within safe limits.
- Describe the importance of the bioactivation process for prodrugs.
- Decipher the mechanisms for drug and chemical-induced toxicity in in vivo and in vitro models and appropriately design and interpret drug screenings.
- Discuss the important role the liver plays in xenobiotic metabolism.
- List the characteristics that enable the kidney to efficiently excrete xenobiotics.
- Recognize system-specific and organ-specific toxic effects on humans and other experimental models.
- Describe the characteristics of the nervous system that make it vulnerable to many toxicants.
