Nature of Genetic Material
How is DNA organized?
- Explain the meaning of ploidy (haploid, diploid, aneuploid etc.) and how it relates to the number of homologues of each chromosome.
- Describe how the positions of individual genes on a given chromosome are related to their positions on the homolog of that chromosome.
- Differentiate between a gene and an allele, including the recognition that genes may have many alleles.
- Explain the functional significance of packaging DNA into chromosomes and the lack of correlation between chromosome size and genetic information content.
- Describe the types of DNA regions that do not encode proteins: the general organization, possible function, and frequency of genes and non-gene DNA sequences in a typical eukaryotic genome.
- Explain what is meant by single-nucleotide polymorphism (SNP) and short tandem repeat (STR), and explain how SNPs and STRs can be used as genetic markers even if they do not cause phenotypic changes.
- Discuss how DNA is packaged in the chromosomes in terms of histones, nucleosomes, and chromatin.
- An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
- CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
- Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
- The Case of the Missing Strawberries: RFLP analysis
- Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
- Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design