How do different types of mutations affect genes and the corresponding mRNAs and proteins?
- Describe how duplications, deletions, inversions, and translocations can affect gene function, gene expression, and genetic recombination. Describe the same for transposable elements.
- Describe how mutations arise and how environmental factors can increase mutation rate.
- Cite examples of mutations that can be beneficial to organisms.
- Interpret results from experiments to distinguish between different types of DNA rearrangements.
- Distinguish between loss of function and gain of function mutations and their potential phenotypic consequences.
- Predict the most likely effects on protein structure and function of null, reduction-of-function, overexpression, dominant-negative and gain-of-function mutations.
- Compare the role of both loss and gain of function mutations in the origin of tumors
- A clicker-based case study that untangles student thinking about the processes in the central dogma
- Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
- Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
- Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon
- Exploration of the Human Genome by Investigation of Personalized SNPs
- Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
- Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
- Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
- Predicting and classifying effects of insertion and deletion mutations on protein coding regions
- Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes