How do different types of mutations affect genes and the corresponding mRNAs and proteins?
- Describe how duplications, deletions, inversions, and translocations can affect gene function, gene expression, and genetic recombination. Describe the same for transposable elements.
- Describe how mutations arise and how environmental factors can increase mutation rate.
- Cite examples of mutations that can be beneficial to organisms.
- Interpret results from experiments to distinguish between different types of DNA rearrangements.
- Distinguish between loss of function and gain of function mutations and their potential phenotypic consequences.
- Predict the most likely effects on protein structure and function of null, reduction-of-function, overexpression, dominant-negative and gain-of-function mutations.
- Compare the role of both loss and gain of function mutations in the origin of tumors
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