Transmission - Patterns of Inheritance
How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?
- Draw a pedigree based on information in a story problem.
- Using pedigrees, distinguish between dominant, recessive, autosomal, X-linked, and cytoplasmic modes of inheritance.
- Predict the transmission of phenotypes associated with maternal effect genes.
- Explain why the terms “dominant” and “recessive” are context dependent and may differ at the cellular level or at the level of a pedigree.
- Calculate the probability that an individual in a pedigree has a particular genotype (using Bayesian inference if appropriate for course).
- Design genetic crosses to provide information about genes, alleles, and gene functions.
- Interpret the results of experiments comparing the phenotypes that result from single mutations in two different genes with the phenotype of the double mutant, contrasting epistatic and additive interactions.
- Explain how continuous traits are the result of many different gene combinations that can each contribute a varying amount to a phenotype.
- Evaluate how genes and the environment can interact to produce a phenotype.
- Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
- Predicting and classifying effects of insertion and deletion mutations on protein coding regions
- Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers
- Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
- Why Meiosis Matters: The case of the fatherless snake