Topic
Cell cycle and cell division
Framing Question
How do cells conduct, coordinate, and regulate nuclear and cell division?
Learning Objectives
- Predict how a mutation or other functional alteration in a cytoskeletal protein will affect the progress of nuclear and cytoplasmic division.
- Defend the argument that the presence of a cell wall in plants and fungi requires a different method for dividing the cytoplasm than that used in animals.
- Evaluate the relative contribution of mutations in tumor suppressor genes and proto-oncogenes in the development of cancer.
- Assess the usefulness and limitations of information obtained from several experimental techniques (i.e., TEM, atomic force microscopy, fluorescent antibody labeling, and confocal fluorescence time lapse microscopy) in dissecting cytoskeletal roles in nuclear and cell division.
- Compare different methods used to coordinate cell division in different cell types.
- Compare and contrast organization of the mitotic spindle in animal, fungal, and plant cells and discuss the evolutionary and functional relevance.
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- Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
