Topic
Protein Targeting & Trafficking
Framing Question
How are cellular components targeted and distributed to different regions and compartments of a cell?
Learning Objectives
- Discuss the differences in structure of a protein occupying its target destination in the cell and immediately after translation from the mRNA.
- Explain the mechanism and function of the unfolded protein response and its value to the cell.
- Compare the general mechanisms that allow some newly synthesized proteins to be released into the cytoplasm, whereas others are directed into other cellular compartments.
- Identify the different cellular compartments in a eukaryotic cell and their main functions in the cell.
- Analyze data to determine the path taken by a protein that normally resides in an organelle/compartment or is secreted from the cell from its site of synthesis to its final destination.
- Given data on effects of drugs and other functional manipulations on entry of various molecules and particles into the cell, determine what pathway is used for entry.
- Compare the molecular recognition events and mechanisms required for movement of proteins through different uptake and secretion pathways.
