Topic
DNA - Information Storage [GENOMICS]
Framing Question
Where are data about the genome found (e.g., nucleotide sequence, epigenomics) and how are they stored and accessed?
Learning Objectives
- Describe how nucleotide sequence data are represented (FASTA, FASTQ, GenBank).
- Describe the nucleotide databases available at NCBI.
- Describe how the NCBI nucleotide databases intersect with other nucleotide databases (EBI, DDBJ, UniProt, etc.).
- Compare and contrast the data contained in different nucleotide databases.
- Search for a sequence record in a nucleotide database with a given accession number.
- Create a collection of nucleotide sequence records that meet a specified criterion (e.g., gene name or symbol).
- Determine the DNA methylation state of a particular region of a genome.
- Describe the types of metadata that accompany sequence data to make for useful biological interpretation (e.g. biological source, accession number, GeneID, journal articles, etc.).
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