Topic
DNA - Information Storage [GENOMICS]
Framing Question
How can bioinformatics tools be employed to analyze genetic information?
Learning Objectives
- Calculate the alignment score between two DNA sequences using a provided scoring matrix.
- Perform a BLASTN search and interpret the results.
- Explain the BLASTN algorithm for nucleotide sequence information.
- Interpret the biological significance of an e-value.
- Annotate a prokaryotic gene (derive a model).
- Annotate a eukaryotic gene (derive a model).
- Create and interpret a multiple sequence alignment (e.g., T-COFFEE, MUSCLE, etc.).
- For a genomic region of interest (e.g., the neighborhood of a particular gene), use a genome browser to view nearby genes, transcription factor binding regions, epigenetic information, etc.
- Describe Hidden Markov Models and how they can be used to assess motifs.
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