Macromolecular Structure Determines Function and Regulation
How is macromolecular structure dynamic?
- Discuss the time scales of various conformational effects in biological macromolecules and design appropriate experiments to investigate ligand induced changes in conformation and dynamics.
- Discuss the structural basis for the dynamic properties of macromolecules and predict the effects of changes in dynamic properties that might result from alteration of primary sequence.
- Predict whether a sequence is ordered or disordered and discuss potential roles for disordered regions of proteins.
- Critically discuss the evidence for and against the roles of dynamics in macromolecular function.