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RNA - Information Transfer [TRANSCRIPTOMICS]

Bioinformatics Learning Framework

Society Learning Goals Articles Sample Learning Objectives
RNA - Information Transfer [TRANSCRIPTOMICS]
Where are data about the transcriptome found (e.g., expression, epigenomics and structure) and how are they stored and accessed?
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  • Identify the euchromatin/heterochromatin boundaries, histone states in a given sequence, and the nucleosome modifications
  • Compare and contrast DNA structure at telomeres and centromeres.
  • Describe the RNA databases available at NCBI (e.g., ESTs, UniGene).
  • Describe the types of metadata that accompany sequence data to make for useful biological interpretation (e.g. biological source, accession number, GeneID, journal articles, etc.).
How can bioinformatics tools be employed to examine transfer of genetic information?
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  • Given a microarray or RNA-seq data file, find the set of significantly differentially expressed genes.
  • Perform motif discovery on the promoter regions of a set of genes identified by a ChIP-seq experiment.
  • Use RNA structure prediction programs (e.g., RNASoft, RNAFold, RNAStructure) to evaluate possible structures for an RNA sequence.
  • Identify the possible different splice isoforms possible from a given gene sequence.

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