Skip to main content

You are here

Computation in the life sciences

Bioinformatics Learning Framework

Society Learning Goals Articles Sample Learning Objectives
Computation in the life sciences
What is the role of computation in hypothesis-driven discovery processes within the life sciences?
show
  • Describe the role of bioinformatics in the scientific research method.
  • Explain the necessity for computation in life sciences research.
  • Explain the role of wet-bench techniques in verifying computational results in life science research.
  • Compare and contrast computer-based research with wet-lab research.
  • Read a scientific article and evaluate how bioinformatics methods were employed by the authors to explore a particular hypothesis.
  • Given a scientific question, develop a hypothesis and define computational approaches that could be used to explore the hypothesis.
  • Evaluate the social, legal, and ethical implications of computational approaches to understanding biology.
What computational concepts are important in bioinformatics?
show
  • Define the term algorithm.
  • Explain the difference between a heuristic (approximate) algorithm and an exact algorithm.
  • Describe the three basic programming structures: sequential, repetition (e.g., while, for) and selection (e.g., if).
  • Use variables and data structures (e.g., lists, arrays, scalars, hash functions).
  • Describe what a regular expression is.
  • Explain the concept of cloud computing.
  • Describe the importance of “big data” in bioinformatics.
  • Describe the means by which “big data” are managed and stored (e.g. dmptool.org).
What statistical concepts are important in bioinformatics?
show
  • Calculate average, median, mode, range, standard deviations for a given data set.
  • Calculate p-values using a t-test for discrete data.
  • Calculate p-values using a z-test for continuous data.
  • Calculate an e-value statistic.
  • Describe the importance of statistical analysis of big data sets.
  • Create a network to illustrate gene interactions.

Announcements

No current announcements