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How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?

Topic

Transmission - Patterns of Inheritance

Framing Question

How can one deduce information about genes, alleles, and gene functions from analysis of genetic crosses and patterns of inheritance?

Learning Objectives

  • Draw a pedigree based on information in a story problem.
  • Using pedigrees, distinguish between dominant, recessive, autosomal, X-linked, and cytoplasmic modes of inheritance.
  • Predict the transmission of phenotypes associated with maternal effect genes.
  • Explain why the terms “dominant” and “recessive” are context dependent and may differ at the cellular level or at the level of a pedigree.
  • Calculate the probability that an individual in a pedigree has a particular genotype (using Bayesian inference if appropriate for course).
  • Design genetic crosses to provide information about genes, alleles, and gene functions.
  • Interpret the results of experiments comparing the phenotypes that result from single mutations in two different genes with the phenotype of the double mutant, contrasting epistatic and additive interactions.
  • Explain how continuous traits are the result of many different gene combinations that can each contribute a varying amount to a phenotype.
  • Evaluate how genes and the environment can interact to produce a phenotype.

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