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Where are data about the proteome found (e.g., amino acid sequence and structure) and how are they stored and accessed?

Topic

Protein - Information in Action [PROTEOMICS]

Framing Question

Where are data about the proteome found (e.g., amino acid sequence and structure) and how are they stored and accessed?

Learning Objectives

  • Describe how protein sequence data are represented (e.g., FASTA, GenBank, etc.)
  • Describe the different protein databases available at NCBI (sequence, structure, function).
  • Describe how the NCBI databases intersect with other databases (e.g., EBI, DDBJ, UniProt, etc.).
  • Compare and contrast data contained in different databases.
  • Search for a protein record in a database with a given accession number.
  • Create a collection of records that meet a specified criterion (e.g., gene name or symbol).
  • Describe the types of metadata that accompany sequence, structure, and function data to make for useful biological interpretation (e.g. biological source, accession number, UniProt number, journal articles, etc.).

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