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Where are data about the genome found (e.g., nucleotide sequence, epigenomics) and how are they stored and accessed?

Topic

DNA - Information Storage [GENOMICS]

Framing Question

Where are data about the genome found (e.g., nucleotide sequence, epigenomics) and how are they stored and accessed?

Learning Objectives

  • Describe how nucleotide sequence data are represented (FASTA, FASTQ, GenBank).
  • Describe the nucleotide databases available at NCBI.
  • Describe how the NCBI nucleotide databases intersect with other nucleotide databases (EBI, DDBJ, UniProt, etc.).
  • Compare and contrast the data contained in different nucleotide databases.
  • Search for a sequence record in a nucleotide database with a given accession number.
  • Create a collection of nucleotide sequence records that meet a specified criterion (e.g., gene name or symbol).
  • Determine the DNA methylation state of a particular region of a genome.
  • Describe the types of metadata that accompany sequence data to make for useful biological interpretation (e.g. biological source, accession number, GeneID, journal articles, etc.).

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