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How is the biological activity of macromolecules regulated?

Topic

Macromolecular Structure Determines Function and Regulation

Framing Question

How is the biological activity of macromolecules regulated?

Learning Objectives

  • Compare and contrast various mechanisms for regulating the function of a macromolecule or an enzymatic reaction or pathway.
  • Discuss the advantages and disadvantages of regulating a reaction allosterically
  • Discuss examples of allosteric regulation, covalent regulation and gene level alterations of macromolecular structure-function.
  • Use experimental data to assess the type of regulation in response to either homotropic or heterotropic ligands on a macromolecule.
  • Design a model to explain the regulation of macromolecule structure-function.
  • Describe how evolution has shaped the regulation of macromolecules and processes
  • Describe how changes in cellular homeostasis affect signaling and regulatory molecules and metabolic intermediates.

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