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How are a variety of experimental and computational approaches used to observe and quantitatively measure the structure, dynamics and function of biological macromolecules?

Topic

Macromolecular Structure Determines Function and Regulation

Framing Question

How are a variety of experimental and computational approaches used to observe and quantitatively measure the structure, dynamics and function of biological macromolecules?

Learning Objectives

  • Propose a purification scheme for a particular molecule in a mixture given the biophysical properties of the various molecules in the mix.
  • Explain how computational approaches can be used to explore protein-ligand interactions and discuss how the results of such computations can be explored experimentally
  • Either propose experiments that would determine the quaternary structure of a molecule or interpret data pertaining to tertiary and quaternary structure of molecules
  • Compare and contrast the computational approaches available to propose a three dimensional structure of a macromolecule and discuss how the proposed structure could be validated experimentally.
  • Analyze kinetic or binding data to derive appropriate parameters and assess the validity of the model used to describe the phenomenon.

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